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新加坡在加强针的接种上，走得更远。2022年4月22日，所有80岁以上的高龄老人、住在养老院或60~79岁有重病风险的医疗弱势群体，被建议接种第二针加强针。与此同时，新加坡卫生部更改了“完全接种（两针mRNA或三针灭活）”的概念，在新的界定中，“最低保护”的疫苗接种，是指接种三针mRNA/重组蛋白Novavax疫苗或四针灭活疫苗。在此之上，老年人或有基础病等高危人群被建议再接种一剂加强针，也就是说，在新加坡，很多老人可能已接种了五针灭活疫苗。
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